Calendrier PSG
| 10/09/2020 | 21:00 | Racing Club de Lens | 1 | 0 | Paris Saint-Germain FC |
| 13/09/2020 | 21:00 | Paris Saint-Germain FC | 0 | 1 | Olympique de Marseille |
| 16/09/2020 | 21:00 | Paris Saint-Germain FC | 1 | 0 | FC Metz |
| 20/09/2020 | 13:00 | OGC Nice | 0 | 3 | Paris Saint-Germain FC |
| 27/09/2020 | 21:00 | Stade de Reims | 0 | 2 | Paris Saint-Germain FC |
| 02/10/2020 | 21:00 | Paris Saint-Germain FC | 6 | 1 | Angers SCO |
| 16/10/2020 | 21:00 | Nîmes Olympique | 0 | 4 | Paris Saint-Germain FC |
| 20/10/2020 | 21:00 | Paris Saint-Germain FC | 1 | 2 | Manchester United FC |
| 24/10/2020 | 21:00 | Paris Saint-Germain FC | 4 | 0 | Dijon Football Côte d'Or |
| 28/10/2020 | 19:55 | Medipol Başakşehir FK | 0 | 2 | Paris Saint-Germain FC |
| 31/10/2020 | 22:00 | FC Nantes | 0 | 3 | Paris Saint-Germain FC |
| 04/11/2020 | 22:00 | RB Leipzig | 2 | 1 | Paris Saint-Germain FC |
| 07/11/2020 | 22:00 | Paris Saint-Germain FC | 3 | 0 | Stade Rennais FC 1901 |
| 20/11/2020 | 22:00 | AS Monaco FC | 3 | 2 | Paris Saint-Germain FC |
| 24/11/2020 | 22:00 | Paris Saint-Germain FC | 1 | 0 | RB Leipzig |
| 28/11/2020 | 22:00 | Paris Saint-Germain FC | 2 | 2 | FC Girondins de Bordeaux |
| 02/12/2020 | 22:00 | Manchester United FC | 1 | 3 | Paris Saint-Germain FC |
| 05/12/2020 | 22:00 | Montpellier HSC | 1 | 3 | Paris Saint-Germain FC |
| 09/12/2020 | 19:55 | Paris Saint-Germain FC | 5 | 1 | Medipol Başakşehir FK |
| 13/12/2020 | 22:00 | Paris Saint-Germain FC | 0 | 1 | Olympique Lyonnais |
| 16/12/2020 | 22:00 | Paris Saint-Germain FC | 2 | 0 | FC Lorient |
| 20/12/2020 | 22:00 | Lille OSC | 0 | 0 | Paris Saint-Germain FC |
| 23/12/2020 | 22:00 | Paris Saint-Germain FC | 4 | 0 | RC Strasbourg Alsace |
| 06/01/2021 | 22:00 | AS Saint-Étienne | 1 | 1 | Paris Saint-Germain FC |
| 09/01/2021 | 22:00 | Paris Saint-Germain FC | 3 | 0 | Stade Brestois 29 |
| 16/01/2021 | 22:00 | Angers SCO | 0 | 1 | Paris Saint-Germain FC |
| 22/01/2021 | 22:00 | Paris Saint-Germain FC | 4 | 0 | Montpellier HSC |
| 31/01/2021 | 16:00 | FC Lorient | 3 | 2 | Paris Saint-Germain FC |
| 03/02/2021 | 22:00 | Paris Saint-Germain FC | 3 | 0 | Nîmes Olympique |
| 07/02/2021 | 22:00 | Olympique de Marseille | 0 | 2 | Paris Saint-Germain FC |
| 13/02/2021 | 18:00 | Paris Saint-Germain FC | 2 | 1 | OGC Nice |
| 16/02/2021 | 22:00 | FC Barcelona | 1 | 4 | Paris Saint-Germain FC |
| 21/02/2021 | 22:00 | Paris Saint-Germain FC | 0 | 2 | AS Monaco FC |
| 27/02/2021 | 18:00 | Dijon Football Côte d'Or | 0 | 4 | Paris Saint-Germain FC |
| 03/03/2021 | 22:00 | FC Girondins de Bordeaux | 0 | 1 | Paris Saint-Germain FC |
| 10/03/2021 | 22:00 | Paris Saint-Germain FC | 1 | 1 | FC Barcelona |
| 14/03/2021 | 22:00 | Paris Saint-Germain FC | 1 | 2 | FC Nantes |
| 21/03/2021 | 22:00 | Olympique Lyonnais | 2 | 4 | Paris Saint-Germain FC |
| 03/04/2021 | 17:00 | Paris Saint-Germain FC | 0 | 1 | Lille OSC |
| 07/04/2021 | 21:00 | FC Bayern München | 2 | 3 | Paris Saint-Germain FC |
| 10/04/2021 | 17:00 | RC Strasbourg Alsace | 1 | 4 | Paris Saint-Germain FC |
| 13/04/2021 | 21:00 | Paris Saint-Germain FC | 0 | 1 | FC Bayern München |
| 18/04/2021 | 13:00 | Paris Saint-Germain FC | 3 | 2 | AS Saint-Étienne |
| 24/04/2021 | 17:00 | FC Metz | 1 | 3 | Paris Saint-Germain FC |
| 28/04/2021 | 21:00 | Paris Saint-Germain FC | 1 | 2 | Manchester City FC |
| 01/05/2021 | 17:00 | Paris Saint-Germain FC | 2 | 1 | Racing Club de Lens |
| 04/05/2021 | 21:00 | Manchester City FC | 2 | 0 | Paris Saint-Germain FC |
| 09/05/2021 | 21:05 | Stade Rennais FC 1901 | 1 | 1 | Paris Saint-Germain FC |
| 16/05/2021 | 21:00 | Paris Saint-Germain FC | | | Stade de Reims |
| 23/05/2021 | 21:00 | Stade Brestois 29 | | | Paris Saint-Germain FC |